ISSN 2379-8203
BIOMEDICINE & NURSING
Biomedicine and Nursing
Quarterly
Volume 11 - Issue 1 (Cumulated No. 40), March 25, 2025 (COVER)
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1. Hippotherapy simulator would improve stability in patients with multiple sclerosis
Running title: Hippotherapy simulator in MS
Yaghoub Salek Zamani MD1, Hormoz Ayramlou MD2, Homayoun Sadeghi-Bazargani MD3, Salim Vahedi Namin MD1, Saeid Siahi MD1, Navid Heidari MD4, Sahar Salek Zamani MD1, Afshin Habibzadeh MD4
1 Physical medicine and rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Dept. of Neurology, Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Dept. of Statistics & Epidemiology, Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Corresponding author: Saeid Siahi, Physical medicine and rehabilitation Research Center, Tabriz University of Medical Sciences, Golbad Ave., Tabriz, Iran; Zip code: Zip code: 5166615556; Tel: +98 411 – 3373967; Fax: +98 411 – 3373967; E-mail: saeid.siahi@yahoo.com
Abstract: Multiple sclerosis (MS) causes various problems due to progressive disease with different disabilities and complications. Rehabilitation is performed with the aim of increasing activity and improving independence in patients with MS. We aim to evaluate the effects of hippotherapy on stability in patients with MS. In this clinical trial, 28 MS patients (67.9% female with mean age of 41.28±9.79 years) received 30 minutes of treatment with hippotherapy simulator device 3 sessions a week for 12 weeks. Falling risk, postural stability, Berg Balance Scale (BBS) and Expanded Disability Status Scale (EDSS) before and each four weeks after the intervention were evaluated. Falling risk, postural stability, BBS and EDSS were significantly improved during treatment period (p<0.001). Sixteen patients (57.14%) had more than 10% improvement. Cox regression analysis showed no relation between time to BBS improvement and hippotherapy (p=0.026). Using hippotherapy simulator would improve postural stability and fall risk in MS patients. However, patients do not have same improvement. Further studies are needed to evaluate the exact efficacy of this device.
[Yaghoub Salek Zamani MD, Hormoz Ayramlou MD, Homayoun Sadeghi-Bazargani MD, Salim Vahedi Namin MD, Saeid Siahi MD, Navid Heidari MD, Sahar Salek Zamani MD, Afshin Habibzadeh MD. Hippotherapy simulator would improve stability in patients with multiple sclerosis. Biomedicine and Nursing 2025;11(1):1-5]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 01. doi:10.7537/marsbnj110125.01
Keywords: Multiple sclerosis; Hippotherapy; Stability
2. A Novel Label-free Biosensor Based on Circular Fractals
Kiana Malmir 1, Hamidreza Habibiyan 1 and Hassan Ghafoorifard 1, 2
1 Photonics Engineering Group, Amirkabir University of Technology, Hafez Ave, Tehran, Iran
2 Department of Electrical Engineering, Amirkabir University of Technology, Hafez Ave, Tehran, Iran
habibiyan@aut.ac.ir
Abstract: In this paper, we propose and analyze a fractal structure-based biosensor in a silicon-on-insulator (SOI) platform. Fractal architecture is a novel structure in order to use in biosensor design. The suggested biosensor offers potential for real time detection of biomolecule interactions the specific targets in the analyte because of having the sensitivity toward surface binding events. In biosensor based on fractal structure, sensitivity and notch deep are developed in comparison with a lone disk. An SOI optical fractal consisted of uniformly distributed disks with radius of 0.1 micron meter is capable of detecting bulk refractive index changes of 10−4. Its sensitivity demonstrated to this refractive index change is 400nm/RIU and 17×104dB/RIU.
[Malmir K, Habibiyan H. and Ghafoorifard H, A Novel Label-free Biosensor Based on Circular Fractals. Biomedicine and Nursing 2025;11(1):6-10]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 02. doi:10.7537/marsbnj110125.02
Keywords: integrated optic; biosensor; fractal; microresonator
3. Synthesis and biological evaluation of 2,4-diaminoquinazolines as potential antitumor agents
Mohammad A. Alassaf, Khalid B. Selim, Magda N. A. Nasr
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
khbselim2000@yahoo.com
Abstract: In the present study, a set of 2-anilino-4-alkylaminoquinazoline derivatives was synthesized and tested for their antitumor activities in vitro against a panel of four human cancer cell lines and for their DNA-binding affinity. Among the synthesized compounds, 4c and 5b with 4-substitution at the phenyl ring were found to have the higher inhibitory effect against MCF-7 (breast adenocarcinoma), HCT-116 (colon cancer), HePG-2 (hepatocellular carcinoma), and HFB4 (human skin cancer). Further investigation revealed that compounds 4a and 5d exhibited better affinity to bind with DNA than other tested compounds.
[Mohammad A. Alassaf, Khalid B. Selim, Magda N. A. Nasr. Synthesis and biological evaluation of 2,4-diaminoquinazolines as potential antitumor agents. Biomedicine and Nursing 2025;11(1):11-17]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 03. doi:10.7537/marsbnj110125.03
Key words: synthesis; anticancer; quinazolines; DNA-binding
4. Clinicopathological correlations of biopsy proven renal disease In Minia University Hospital
Hisham Mostafa Tawfik, MD
Nephrology unit, Minia University, Egypt
Corresponding author
Hisham Mostafa Tawfik, MD
01142741126
Mahmoud.znaty@yahoo.com
Abstract:
Background: Glomerular disease (GD) is one of the most common forms of renal diseases and can have many different clinical presentations. It can present as nephrotic syndrome (NS), nephritic syndrome, rapidly progressive renal failure (RPRF), acute kidney injury (AKI), chronic kidney disease(CKD), macroscopic hematuria (MH), recurrent disease in the post-transplant kidney, as well as isolated proteinuria or hematuria. In any case, a kidney biopsy is needed for the correct characterization of various types of GD.
Aim of the work: To comprehensive information about the demographics, clinical presentation and pattern of kidney diseases diagnosed by renal biopsy in Minia Univrsity Hospital.
Patients and Methods: The study included 104 patients admitted to renal unit at El-Minia university hospital with mean ages 31.65±13.77 years. These patients selected from January 2014 to Augest 2016.This study included 40 patients retospectively from January 2014 to March 2015 and continued prospectively for 64 patients from April 2015 to Augest 2016.
Results: All renal biopsy specimens obtained were prepared as the standard protocol analysis included light microscopy (LM) . In Our Study, the most common renal diseases was Lupus Nephritis (27.9%), followed by membranoproliferative glomerulonephritis (15.4%) , focal segmental glomerulosclerosis (13.5%),tubulointerstitial nephritis (11.5%), amyloidosis (7.7%) , crescentic glomerulonephritis (5.8%), thrombotic microangiopathy (4.8%), vascular nephropathies (3.8%), minimal change disease (3.8%), membranous nephropathy (2.9%), postinfectious glomerulonephritis (1.9%) and diabetic nephropathy (1%).
Conclusion: The most often diagnosed glomerular disease in our study was lupus nephritis which was the main cause of secondary kidney disease followed by membranoproliferative glomerulonephritis and focal segmental glomerulosclerosis.
[Hisham Mostafa Tawfik. Clinicopathological correlations of biopsy proven renal disease In Minia University Hospital. Biomedicine and Nursing 2025;11(1):18-33]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 04. doi:10.7537/marsbnj110125.04
Keywords: Clinicopathological; biopsy; renal disease
5. Modulatory Effect of Quercetin on Silymarin in Carbon Tetrachloride-Induced Hepatotoxicity in Rats
Lamia A. Ahmed, Reem M.Galal, Hala F. Zaki, Sanaa A. Kenawy.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Authors:
Lamiaa A. Ahmed, Associate Professor of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Egypt.
E-mail: lamiaa.ahmed@pharma.cu.edu.eg
Reem M. Galal, Assistant Lecturer of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Egypt.
E-mail: reemgalal82@gmail.com
Hala F. Zaki, Professor of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Egypt.
E-mail: hala.fahmy@pharma.cu.edu.eg
Sanaa A. Kenawy, Professor of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Egypt.
E-mail: sanaa.kenawy@pharma.cu.edu.eg
Corresponding author: Lamiaa A. Ahmed
Postal address: Faculty of Pharmacy, Kasr El Aini St., Cairo, Egypt
Postal code: 11562
Fax number: 00202-23628426
Mobile number: 00201002205840
E-mail: reemgalal82@gmail.com
Abstract: Background: Hepatotoxic injury can have several forms including necrosis, steatosis, fibrosis, cirrhosis and carcinoma. The present study was undertaken to investigate the hepatoprotective effect of quercetin and its modulatory effect on silymarin against carbon tetrachloride induced hepatotoxicity in rats. Methods: Male Wistar rats were divided into five groups where CCl4 (0.5 ml/kg; p.o.; twice/week for 4 weeks) was administered to all groups except the normal one. The remaining groups received silymarin (100 mg/kg), quercetin (50 mg/kg) and a combination of silymarin (100 mg/kg) and quercetin (50 mg/kg), respectively. Results: CCl4 caused marked liver damage as manifested by significant increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities. It also resulted in a significant decrease in liver reduced glutathione (GSH) content parallel to a significant increase in malondialdehyde (MDA), inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) hepatic contents. Combined therapy provided significant improvement compared to silymarin alone regarding the amelioration of serum transaminases as well as oxidative stress and inflammatory biomarkers. Results of histopathological examination were also correlated with the biochemical findings. Conclusion: Quercetin could be used as effective hepatoprotective agent against CCl4-induced liver damage by attenuation of oxidative stress as well as the inflammatory response in the liver. Moreover, our results demonstrated that quercetin potentiates the hepatoprotective effect of silymarin in CCl4-induced hepatotoxicity.
[Lamia A. Ahmed, Reem M. Galal, Hala F. Zaki, Sanaa A. Kenawy. Biomedicine and Nursing 2025;11(1):34-44]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 05. doi:10.7537/marsbnj110125.05
Key words: carbon tetrachloride; hepatotoxicity; quercetin; silymarin.
6. Periodontal diseases and adverse pregnancy outcomes: is there a relation?
Ahmed A. M. Nasr, Faisal Ali Mustafa, Mahammad G. Nasr, Abd El-Naser Abd El-Gaber Ali, Hossam Alktatny
Obstetrics and Gynecology Department- faculty of Medicine - Al-Azhar University. (Assiut). Egypt
aam_nasr@yahoo.com
Abstract: Periodontal disease (PD) is one of the most common chronic disorders of infectious origin known in humans. Maternal periodontal disease is a chronic oral infection with local and systemic inflammatory responses and may be associated with adverse pregnancy outcomes. Objective: To evaluate whether or not periodontal disease (PD) in pregnancy is associated with adverse pregnancy outcomes, and to find the possible pathogenesis of these adverse outcomes if present. Patients and methods: 300 pregnant women were assessed for periodontal status by the criteria commonly used in epidemiological studies, probing depth (PD) and clinical attachment level (CAL). Women were then classified according to periodontal status in tow patient groups (145 pregnant women with periodontitis) and control group (155 pregnant women without periodontitis). For all participants C-reactive protein (CRP) assay was performed, follow up of all participants until delivery was done to evaluate obstetric complications associated with each group. Results: PD is associated significantly with adverse pregnancy outcomes as preeclampsia, gestational diabetes, preterm labor, low birth weight, and prelabor rupture of membranes (p<0.05). The mean + SD levels of CRP was 75.8% higher among patient group compared to control group and the difference was statistically significant (2.55 +0.52 vs. 1.45 + 0.22). Conclusions: This study supports the hypothesis of an association between periodontal disease and adverse pregnancy outcomes. The study also suggests that CRP in periodontitis may mediate the effect of periodontitis on pregnancy outcomes.
[Ahmed A. M. Nasr, Faisal Ali Mustafa, Mahammad G. Nasr, Abd El-Naser Abd El-Gaber Ali, Hossam Alktatny. Periodontal diseases and adverse pregnancy outcomes: is there a relation? Biomedicine and Nursing 2025;11(1):45-53]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 06. doi:10.7537/marsbnj110125.06
Key words: periodontal disease; adverse pregnancy outcomes; CRP
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