BIOMEDICINE & NURSING


ISSN 2379-8203

Biomedicine and Nursing
Quarterly
Volume 7 - Issue 4 (Cumulated No. 27), December 25, 2021.
 (COVER)
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1. Effect of evidence-based infection prevention and control guideline on pediatric nurses' practice in neonatal intensive care units
Dr. Eman Abd-Elaziz Mohamed1*, Eman Ahmed Abd-Elmawgood2
1Lecturer of pediatric Nursing, Pediatric Nursing Department, Faculty of Nursing, South Valley University, Egypt
2Lecturer of pediatrics, Pediatric Department, Faculty of Medicine, South Valley University, Egypt
Email: dreman.ahmed@nurs.svu.edu.eg


Abstract: Background: Infection control is essentially a clinical service directly related to improving and maintaining the quality of patient care. Aim: To determine the effect of evidence-based infection control guidelines on pediatric nurses' practice in NICU. Research design: A Pre/post-quasi-experimental research design was utilized to meet the aims of this study. The study was carried out at Qena university hospital who is working in neonatal care units. A convenient sample of 30 nurses was included in this study. Educational program for nurses was done through using the following data collection tools 1) socio-demographic data, 2) An observation guideline.3) Educational training practice program. Results: There was a significant increase in the total performance means score after one month of the program (119.20 ± 6.14) than their means score before initiation of the program (82.07 ± 8.95) (p<0.001. Conclusion: Infection prevention and control practices can be improved pediatric nurse's performance by the implementation of evidence-based infection prevention and control guidelines. Recommendations: Regular training sessions and workshops for nurses and health team members should be organized by official institutions on infection prevention and control guidelines in NICUs.
[Eman Abd-Elaziz Mohamed, Eman Ahmed Abd-Elmawgood. Effect of evidence-based infection prevention and control guideline on pediatric nurses' practice in neonatal intensive care units. Biomedicine and Nursing 2021;7(1): 1-12]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 1. doi:10.7537/marsbnj070121.01.
Keywords: evidence-based - infection prevention and control - guideline -pediatric nurses' practice – NICU


​2. Assess the Awareness of Evidence Based Practice among Nurses at Tertiary care Hospital
Aftab Ahmed Memon1, Parveen Akhter 2, Zohaib Hassan Memon3 and Awais Ahmed4
1. Peoples Nursing School Liaquat University of Health Sciences, Jamshoro, Pakistan
2. Assistant Professor PNS, Faculty of Community Medicine & Public Health Science Liaquat University of Health Sciences, Jamshoro, Pakistan
3. Institute of Mathematics and Computer Science, University of Sindh, Jamshoro, Pakistan
4. Staff Nurse, WAPDA Hospital Hyderabad, Sindh.


Abstract: Background: Evidence-Based Nursing a process of making clinical decisions on the basis of the best available evidence supported by research, their clinical experience and patient preferences in the context of available resources. Material and Methods: A descriptive Cross-sectional study carried out at LUMHS Hyderabad / Jamshoro for three months after the approval of synopsis. Participants in the study filled questionnaires which comprises in two sections: the demographic and EBP-related data. For this analysis, the demographic data questionnaire was developed by the authors and included: age, gender, educational achievement, current work role, overall years of experience and period and duration of nursing profession. Results:The study included a total of 350 subjects which consisted of 100 males (28.6%) and 250 females (71.4%) with mean age 30±. A significant relation was found between knowledge about evidence based nursing practice (P value =<0.001) and many variables of interest. Conclusion: Evidence based practice among nurses has been inadequate in tertiary care facility of Hyderabad. Most of the nurses felt difficulty in providing nursing care and facing stress during nursing care delivery. Lack of facilities and manpower at public hospital affect the evidence based practice.
[Aftab Ahmed Memon, Parveen Akhter, Zohaib Hassan Memon and Awais Ahmed. “Assess the Awareness of Evidence Based Practice among Nurses at Tertiary care Hospital”. Biomedicine and Nursing 2021;7(1): 13-21]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 2. doi:10.7537/marsbnj070121.02.
Keywords: Evidence-based nursing, Tertiary Care Centers, Patient Preference, Surveys and Questionnaires


3. Study of Corneal Endothelial Changes after Intravitreal Injection of Ranibizumab (Lucentis) in Cases of Retinal Vein Occlusion
Radwa Nabil Mohamed Shokeir (MSCh), Mohamed Sameh El Shorbagy (MD), Moataz Mohamed Sabry (MD), Amr Fawzy Sharaf (MD)
Ophthalmology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
rnsh123@gmail.com


Abstract: Introduction: Intravitreal ranibizumab (Lucentis®) is an effective short-term treatment for (retinal neovascularization) and persistent macular edema secondary to retinal vein occlusion (RVO). Intravitreal ranibizumab may cause changes in the corneal endothelium. Aim: The aim of this study is to evaluate corneal endothelial changes after intravitreal injection of Ranibizumab (Lucentis) in cases of Retinal Vein Occlusion. Patients and Methods: This prospective case series study included 30 patients with RVO to evaluate corneal endothelial changes by Specular microscopy after intravitreal injection of ranibizumab. Results: There was an insignificant difference between before and one month after the last intravitreal injection as regard to endothelial cell density, coefficient of variation in cell size and hexagonality of endothelial cells (P = 0.614, 0.677 and 0.687). Conclusion: Repeated intravitreal injections of ranibizumab (Lucentis®) don’t seem to cause substantial changes in the corneal endothelium by specular microscopy after one month after finishing three times of injection in RVO patients.
[Radwa Nabil Mohamed Shokeir, Mohamed Sameh El Shorbagy, Moataz Mohamed Sabry, Amr Fawzy Sharaf. Study of Corneal Endothelial Changes after Intravitreal Injection of Ranibizumab (Lucentis) in Cases of Retinal Vein Occlusion. Biomedicine and Nursing 2020;6(4): 22-25]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 3. doi:10.7537/marsbnj060420.03.
Keywords: Corneal Endothelial, Ranibizumab (Lucentis), Retinal Vein


4. A Medicinal Plant’s Extract Effective on Osteoarthritis 
Adekunle Odunayo Adejuwon 1, 2, 3, 4*, Olaleke David Odeleye 4, Okikioluwa Ayoade Odewale 5, Victoria Anatolyivna Tsygankova 6, Marina V. Donova 7

1 Department of Biological Sciences, Faculty of Science, Kings University, Ode-Omu, Osun State, Nigeria
2 National Research Foundation of Ukraine (NRFU), Maksymovych Scientific Library of The Taras Shevchenko Kyiv National University Kyiv, Volodymyrska Street 58, Office Number 38 Ukraine, East Europe 
3 The European Science Foundation College of Expert Reviewers (The European Union (EU)); and The European Science Foundation College of Review Panel Members (The European Union (EU)), Offices: 1, Quai Lezay-Marnésia - BP 90015, 67008 Strasbourg Cedex, France, Western Europe
4 Medwave Company Limited, Istanbul, Istanbul Province, Republic of Turkey, Southeastern Europe/Western Asia
5 Department of Nursing, Lead City University, Ibadan, Nigeria
6 Department for Chemistry of Bioactive Nitrogen-Containing Heterocyclic Compounds, Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine, 1, Murmanskaya Str., 02660, Kyiv, Ukraine
7 G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino, 5, 142290, Moscow, Russian Federation, East Europe

e-mail address: ao_adejuwon@yahoo.ca


Abstract: Background: Infection with bacteria or viruses including HIV, parvovirus, alpha viruses, hepatitis viruses B and C can lead to acute or chronic forms of arthritis. Arthritis seems prevalent in women than in men in the United States of America. It affects the middle aged and aged in Nigeria, West Africa. Osteoarthritis has been reported to affect 0.4% of the populace in the Nigerian rural setting. Investigation: 500g of the root bark of Philenoptera cyanescens was ground and added to 1L of 95% alcohol (Sigma-Aldrich). The extract was left overnight for 24 hr. The extract was filtered and concentrated to about one-sixth of its original volume in vacuo using a rotary evaporator (Quick fit, Rotavapor-R, Buchi, Switzerland) at 30oC under low vacuum pressure and low evaporation. 100ml of the concentrated extract was given orally to ten human subjects (n= 5 males; n=5 females) diagnosed with osteoarthritis. The ten subjects were diagnosed with osteoarthritis at the Medical Out-Patient (MOP) Unit of the University College Hospital, Ibadan, Nigeria. Oral application of extract to subjects was immediately after meal on a daily basis for a period of eight days. Observation: All subjects were able to walk properly within eight days of oral application of plant’s extract. Ability to walk properly improved gradually after the period of the oral application. Conclusion: The concentrated alcohol extract the root bark of Philenoptera cyanescens was effective and improved the ability to walk in patients with osteoarthritis.
[Adejuwon AO, Odeleye OD, Odewale OA, Omololu-Aso J, Tsygankova VA. A Medicinal Plant’s Extract Effective on Osteoarthritis. Biomedicine and Nursing 2021;7(1): 26-28]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 4. doi:10.7537/marsbnj070121.04.
Keywords: Osteoarthritis; Philenoptera cyanescens; Root bark; Alcohol extract; Infection


5. Ethnobotanical and Medicinal Uses of Some Wild Edible Fruiting Plants in District Tehri Garhwal (Western Himalaya), Uttarakhand
* P S Chauhan **MPS Parmar and ***Indu Tiwari 
*,*** Department of Botany, Govt. PG College Rishikesh, Uttarakhand, India 
**Department of Botany, Govt. PG College Uttarkashi Uttarakand, India 
Correspondance author: drpschauhan17@gmail.com


Abstract: The present study was conducted to explore ethnomedicinal uses of different wild edible fruiting plants by inhabitants in district Tehri Garhwal (Uttarakhand). Study was carried out in District Tehri Garhwal, and twenty-four wild fruits viz; Aegle marmelos, Benthamidia capitata, Berberis aristata, Berberis lyceum, Carissa opaca, Celtis australis, Embilica officinalis, Ficus auriculata, Ficus palmate, Ficus racemosa, Ficus semicordata, Flacourtia indica, Grewia optiva, Morus serrata, Myrica esculenta, Phoenix humilis, Punica granatum, Pyrus pashia, Rhus parviflora, Rubus ellipticus, Rubus paniculatus, Solanum nigrum, Syzygium cumini, and Ziziphus glaberrima were identified from study area and their ethnomedical uses have been noticed.
[P S Chauhan MPS Parmar and Indu Tiwari. Ethnobotanical and Medicinal Uses of Some Wild Edible Fruiting Plants in District Tehri Garhwal (Western Himalaya), Uttarakhand. Biomedicine and Nursing 2021;7(1): 29-33]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 5. doi:10.7537/marsbnj070121.05. 
Keywords– Wild fruits, nutrition, protein, medicines, ethnobotanical, hilly areas, consumption.


6. Widespread Dermatophytosis Mimicking Other Dermatoses
Hamed Mohamed Abdo
Professor of Dermatology, Dermatomycology Unit, Department of Dermatology, Faculty of Medicine, Al Azhar University, Cairo 11633, Egypt
E-mail: hamed392@yahoo.com; Phone: +20(2)25128989; Fax number: +20(2)25065571


Abstract:A 63-year-old farmer had presented with extensive, widespread tinea corporis and fingernail and toenail onychomycosis for 7 years. Erythematous

patches were present all over the body including scalp, palms, and soles while sparing only few small areas on the trunk. All nails were also involved and showed varying degrees of onycholysis, subungual hyperkeratosis and pigmentation. The case had been misdiagnosed as eczema or psoriasis by some and was treated unsuccessfully with various topical and systemic medications for several years. Direct microscopy showed septate and branched hyphae and fungal cultures from skin and nails identified Trichophyton rubrum. The patient was treated for 10 weeks with oral ultramicronized griseofulvin 12.5 mg/kg/day, topical miconazole 2% cream and povidone iodine 7.5% shampoo with complete clinical and mycological cure of all skin lesions. A possibility of fungal infection in any generalized scaly erythematous lesions, especially when not responding to anti-eczematous treatment, should be considered. 

[Hamed Mohamed Abdo. Widespread Dermatophytosis Mimicking Other Dermatoses. Biomedicine and Nursing 2021;7(1): 34-40]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 6. doi:10.7537/marsbnj070121.06.
Keywords: widespread dermatophytosis, tinea corporis, T. rubrum.


7. Role of Diagnostic Laparoscopy in Management of Acute Abdomen of Unknown Aetiology
Prof. Dr/ Mahmoud Ahmed El-Shaf’ey, Assis. Prof. Dr/ Hesham Mohamed Ali Omran, Dr/ Mohamed Gamal Abd El-Rahman & Reda Harby Marzouk Mithany 
General Surgery Department, Faculty of Medicine, Ain Shams University
Corresponding Author: Reda Harby Marzouk Mithany
Phone No.: (+2) 01277240889
E-mail: reda7rby@gmail.com


Abstract: Background: Acute abdominal pain (AAP) is a medical emergency, characterized by pain arising from the abdominal area, of non-traumatic origin with a maximum duration of five days. It is the most common surgical emergency, one of the most common reasons for referral to an emergency department (ED) and the most common cause for non-trauma-related hospital admissions. Aim of the Work: To evaluate the role of laparoscopy in the diagnosis and treatment of unexplained acute abdominal pain and establish it instead of conventional exploratory laparotomy. Patients and Methods: The current study is a prospective study randomized by closed envelope method which was carried out in Ain Shams University Hospitals. During the period from January 2018 and December 2018. Results: Maximum numbers of patients were of age 26 to 30 years (9 patients i.e. 30.0%). Least number of patients were from age group of 31-35 years. Female patients of acute abdomen were slightly more than that of male patients, due to increased number of cases of acute cholecystitis in females. Most common cause of acute abdomen in this study was acute appendicitis, while least common causes were pelvic inflammatory disease and mickel's diverticulum equally. Laparoscopy was done in all cases (100%); therapeutic laparoscopy was successful in 22 cases (73.30%) while 8 (26.7%) patients required to be converted to laparotomy. Complications related to laparoscopy in our study were observed in 15 out of 30 cases (50%); with shoulder pain is the most common one. Conclusion: Diagnostic Laparoscopy is helpful in confirming a diagnosis made on clinical grounds and laboratory evaluation.

[Prof. Dr/ Mahmoud Ahmed El-Shaf’ey, Assis. Prof. Dr/ Hesham Mohamed Ali Omran, Dr/ Mohamed Gamal Abd El-Rahman & Reda Harby Marzouk Mithany. Role of Diagnostic Laparoscopy in Management of Acute Abdomen of Unknown Aetiology. Biomedicine and Nursing 2021;7(1): 41-50]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 7. doi:10.7537/marsbnj070121.07.
Keywords: Acute abdominal pain - Diagnostic Laparoscopy - Aetiology


8. Assessment of knowledge, practice and factors associated with Tuberculosis prevention among residence in Bati district, Oromiya Zone, Amhara state, Ethiopia 
Hussein Mohammed (Msc in MPH), Dr.Tadesse Guadu (MPH), Mr Malede Fentie (MPH), Teleko Girma (MPH) 

1. university of Gondar College of medicine and Department of public health and veterinary medicine, Gondar, Ethiopia p.o. Box: 196

2. university of Gondar College of medicine and Department of Environmental Health
, Gondar, Ethiopia p.o. Box: 196
3. university of Gondar College of medicine and Department of Public Health Biostatics
, Gondar, Ethiopia p.o. Box: 196
4University of Gondar College of medicine and Department of Public Health and veterinary medicine
, Gondar, Ethiopia p.o. Box: 196
Email: husienmoha660@gmail.com


Abstract: This study was done on residents of Bati district farmers from April to May 2018 to assess the knowledge and practice to prevention of the disease in the area of study. Cross-sectional study design and multistage sampling procedures were employed to select households for this study. The data were collected from785 households, using pretested and structured questionnaire. Data entry was done by using Epi info version 7 statistical software and SPSS version20 soft ware were used for data analysis. Both Bivariable and multiple logistic regressions were fitted. P-value with 95%CI was used and p-value < 0.05 were declared the significant association between knowledge and practice on brucellosis prevention and its associated factors. A total of 806 respondents were participated with a response rate of 97.4% (785). Among those, 785 respondents 682(86.9%) of them were males. Moreover respondents those educated had 2.863 times more likely good knowledge of brucellosis prevention (AOR=2.863, 95%CI: 2.215-3.700) than those not educated. Respondents those that had shared homes with animals were 2.041 times less likely had good practice of brucellosis prevention (AOR=2.041, 95 %CI: 1.091-3.816).
[Hussein Mohammed (Msc in MPH), Dr.Tadesse Guadu (MPH), Mr Malede Fentie (MPH), Teleko Girma (MPH). Assessment of knowledge, practice and factors associated with Tuberculosis prevention among residence in Bati district, Oromiya Zone, Amhara state, Ethiopia. Biomedicine and Nursing 2021;7(1): 51-58]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 8. doi:10.7537/marsbnj070121.08.
Keywords: Bati district, Ethiopia, Brucella, Knowledge, Practice and Associated factors.


9. Serological Surveys Of Maedi Visna Virus In Sheep Population Of Selected Areas Of Eastern Amhara, Ethiopia
Enyiew Alemnew1; Tadiwos Asfaw1; Chekol Demis1; Fasil Aklilu2; Yeshtila Wondifra1
1 Debre Birhan Agricultural Research Centre, Po. Box 112, Debre Birhan Ethiopia
2 National Animal Health Diagnostic and Investigation Centre, Po. Box: 04, Sebeta, Ethiopia


Abstract: Maedi-Visna (MV) causes a significant economical loss through morbidity, mortality and carcass weight loss in sheep worldwide. A cross-sectional study was conducted to determine the prevalence and associations with potential risk factors of Maedi-visna virus infection in the selected areas of the Eastern Amhara. A total of 323 Awsi cross sheep blood sera were collected in the period from November, 2017 to October, 2018 and examined using indirect enzyme linked immune-sorbet assay (i-ELISA) to screen antibodies against Maedi-Visna virus. From a total sample tested 4.0% (13/323) were positive for the presence of antibodies against Maedi visna virus (MVV) in the area. The seroprevalence of Maedi visna was statistically no significantly different between associated risk factors of age (χ2=2.193, p=0.139), sex (χ2=0.288, p=0.591), body condition score (χ2=1.378, p=0.502). This study showed relatively low seroprevalence against Meadi Visna in sheep population in these study areas of the country. Due to difficulty in clinical diagnosis, chronic course of the disease, the absence of effective vaccine and treatment and huge economic loss, a comprehensive epidemiological study all over the country in high sheep population areas should be taken without delay to depict the real picture of the disease in the country.
[Enyiew Alemnew; Tadiwos Asfaw; Chekol Demis; Fasil Aklilu; Yeshtila Wondifra. Serological Survays Of Maedi Visna Virus In Sheep Population Of Selected Areas Of Eastern Amhara, Ethiopia. Biomedicine and Nursing 2021;7(1): 59-64].ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 9. doi:10.7537/marsbnj070121.09.
Key words: Maedi-visna virus; risk factors, seroprevalence and sheep


10. WITHDRAWN

[Biomedicine and Nursing 2021;7(1): 65-70]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org.10. doi:10.7537/marsbnj070121.10. 


11. The First Association of Hb Knossos  : (HBB: c.82G>T) WITH (HBB: c.118C˃T)  Mutation Causs Thalassemia Homozygous in Algerian Children
Belhadi Kamilia1 Gribaa Moez 2 ,  Djaara Hayet1 ,  Ouarhlent Yamina3
1Laboratory of Biotechnology of Bioactive Molecules and Cell Pathophysiology, University of Batna 2, Algeria(05000)
2Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University. Hospital, Sousse, Tunisia
3Department of Hematology, University Hospital of Batna, Algeria


Abstract: Beta-thalassemia is the most common disease among hemoglobinopathies in Algeria. Mutations found in Algerian beta-thalassemia patients constitute a heterogeneous group, consisting mostly of point mutations. Only in very rare cases did deletions or insertions cause affected or carrier phenotypes. Hb Knossos (HBB: c.82G> T) is a rare variant. In this study, we aimed to investigate the effect of compound heterozygosis for Hb Knossos (HBB: c.82G> T) and (HBB: c.118C˃T). To our knowledge, this is the first report of such a combination related with beta-thalassemia major phenotype in a Algerian  family, we used the minisequencing assay as a rapid screening procedure to identify  most common HBB genetic variants and direct DNA sequencing to detect the rare mutations of HBB gene. Heterozygous inheritance of the mutation results in severe beta-thalassemia phenotype. The proband was a 13-year-old boy when first studied. He was referred because of severe anemia. Hematological analysis of the reveals Hb 7.2 g / dl;  with microcytosis of 71.1  fl,   hypochromia 25 pg and  the number of red blood cells is  2.9 106 / mm³ . In addition, a significantly secondary thrombocytosis and leukocytosis were reported in patient. Electrophoresis of hemoglobin in an alkaline medium shows Hb A2 = 4% HbF = 65% and blood smear confirms microcytosis hypochromia, and showing the presence of many dacryocyte with hyper eosinophilia. [The combination of these mutations Hb Knossos (HBB: c.82G> T) and (HBB: c.118C˃T) causes the beta-thalassemia major phenotype, and this is important for genetic counseling. Biomedicine and Nursing 2021;7(1):71-76]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 11. doi:10.7537/marsbnj070121.11.
Keywords:  Beta-thalassemia, Hb Knossos, HBB gene, genetic counseling, Algeria


12. How to consider new approaches in therapeutics?
1.Shah Murad, Professor at Akbar Niazi Teaching Hospital- IMDC, Islamabad-PAKISTAN.
2.Dur Muhammad Sheikh, Prof of Microbiology at JSMU Karachi
3.Fasiha Fatima, AP Biochemistry at KIMS Karachi Pakistan
4.Seema Shah Murad, Gynecologist at NMC Karachi Pakistan
5.Abdul Ghaffar, Community Welfare Officer at IMDC Islamabad.
6.Jamila Shah Murad, Clinical Psychologist at Bahria University, Karachi
Correspondence: DR  MURAD, Deptt of Pharma, IM & DC/ANTH, Islamabad-Pakistan. shahhmurad65@gmail.com, CELL: +923142243415


Abstract: Indicated as adjunctive therapy to diet in adults with hypertriglyceridemia, hyperlipidemia, mixed dyslipidemia, or primary dysbetalipoproteinemia. Tablets and capsules: 10-20 mg PO qDay; not to exceed 40 mg/day. After initiation or upon titration, analyze lipid levels within 2-4 weeks and adjust dosage accordingly. Hypolipidemia can prevent hyperlipidemic patients to be victim of coronary artery disease. This study was conducted to compare hypolipidemic effects of Niacin and Jujube fruit in primary as well as secondary hyperlipidemic patients. Study was conducted from November 2015 to February 2016 at Jinnah Hospital Lahore. Sixty participants were enrolled of both gender male and female patients age range from 20 to 70 years. Consent was taken from all patients. They were divided in two groups. Group-I was advised to take 2 grams Niacin in divided doses for the period of two months. Group-II was advised to take 500 grams of fruit Jujube daily for the period of two months. Their baseline LDL and HDL cholesterol was determined by conventional method of measuring Lipid Profile. After two months therapy, their post treatment lipid profile was measured and mean values with ± SEM were analyzed biostatistically. Group-I which was on Niacin their LDL cholesterol decreased significantly and HDL cholesterol was increased significantly. In group-II patients LDL cholesterol was decreased significantly but HDL increase was not significant with p-value of >0.05. It was concluded from the research work that Niacin is potent in lowering LDL and increasing HDL cholesterol, while Jujube has significant effect as LDL cholesterol lowering potential, but it does not increase HDL cholesterol significantly. [Biomedicine and Nursing 2021;7(1):77-79]. ISSN2379-8211 (print); ISSN2379-8203 (online). http://www.nbmedicine.org. 12. doi:10.7537/marsbnj070121.12
Keywords: approach; therapeutics; adjunctive therapy; diet; adult; hypertriglyceridemia


13. Modified Sinotomy with Marsuplization versus Excision with Lay Open in Treatment of Pilonidal Sinus Disease
Ashraf Farouk Abdeer1, Amr Mohamed Elhefny2, Wadie Boshra Gerges3, John Sobhy Mamlouk Sawires4
Professor of General Surgery, Faculty of Medicine, Ain Shams University
1.Assistant Professor of General Surgery, Faculty of Medicine, Ain Shams University
2.Lecturer of General Surgery, Faculty of Medicine, Ain Shams University
3.M.B.B.Ch Kasr Alainy Faculty of Medicine, Cairo University


Abstract: Pilonidal sinus disease (PSD) is a common infection of the skin in the gluteal cleft, with a prevalence of 0.7% in the general population. Pilonidal sinus can occur in many different areas of the body but most are found in the sacrococcygeal area, in the natal cleft, approximately 5 cm from the anus. This is a prospective comparative randomized study conducted at Department of General Surgery, Imbaba General Hospital to compare the modified sinotomy with marsupialization versus excision with lay open in treatment of pilonidal sinus disease. Pre-study power analysis revealed that a sample size of 30 patients in each group would be sufficient with 80% power and a P value of 0.05. The perfect approach for the management of PNS should be simple, cause minimal pain, have best chance for success and least recurrence rate with low risk for complications, avoid general anesthesia, require minimal wound care, and ensure minimal inconvenience for the patient with rapid return to normal activity. Number of Patients participated in this study were n=60. 77% of the participants were males aged from 17-52 and 26.3 works as drivers. Operative time in modified sinotomy group ranged from 20-40 minutes and in lay open group ranged from 20-35 min (P-value: 0.07). Presence of hair in the back in the modified sinotomy group in 83.3% while in the lay open group 76.6% (P-value: 0.004). In conclusion, we believe that execution of a minimally invasive surgical technique for PSD can be among the most important methods for treating not only primary PSD but also complicated and recurrent PSD cases.[Biomedicine and Nursing 2021;7(1):80-86]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 13. doi:10.7537/marsbnj070121.13.
Keywords: Sinotomy; Marsuplization; Excision; Treatment; Pilonidal; Sinus; Disease


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